Generally yes. From abuse (ie: trying to push WAAY TOO MUCH bass through them, or too much signal distortion (like 6w per channel turned up way too loud).
I've been running 4" Alpine coaxial's in my factory front speaker locations. I have the built in X-over on my amp set for high pass, so only most of the high end & mid range frequency's are going through those speakers. Have yet to replace them. Despite the fact that my Alpine system is 12 years old & is only pushing 35w per channel on the 4 inside speakers, the volume has to be turned up way rediculously loud before distortion sets in. So I know where the speakers limits are... And for the most part, it's not turned up quite that loud anyway.